About IBD

When your doctor talks about inflammatory bowel disease, or IBD, they are usually referring to chronic (long-term or life-long) conditions such as Crohn’s disease (CD) or ulcerative colitis (UC). IBD is not the same as irritable bowel syndrome (IBS), which is a non-inflammatory condition.

Although the exact cause of IBD remains largely unknown, advances in research have improved our understanding of the disease. It is now believed that IBD is caused by a combination of factors including the genes you are born with, an abnormal reaction of the immune system to certain bacteria in your gut, along with an unknown trigger which may be associated with diet or stress.

Watch the video ‘Understanding Inflammatory Bowel Disease (IBD)’ to discover more about IBD and the impact it can have on people living with CD and UC, along with a brief look inside the immune system and its relationship with IBD.

IBD affects around 4.3 million across Europe, and that number is increasing every year. If you have recently been diagnosed with IBD, the ‘My IBD Journey: Life after diagnosis’ animation provides practical advice and positive steps recommended by people living with IBD.

Watch the video 'My IBD Journey: Life after diagnosis' which offers practical advice on positive steps you can take following an IBD diagnosis and how to live well.

This video has been produced by Janssen, in collaboration with the European Federation of Crohn’s and Ulcerative Colitis Associations (EFCCA). For more information about EFCCA, please visit http://www.efcca.org/

Symptoms of IBD

Symptoms can vary depending on the type of IBD, however, some are common across CD and UC:

Some of the less common symptoms include:

These symptoms can come and go, sometimes without warning, and can be caused by triggers such as certain foods or stressful situations, which will be different for each person living with IBD. When the inflammation worsens, and you experience more symptoms of your disease, it is called a ‘flare-up’. The quiet or symptomless period of time between flare-ups is called ‘remission’.

It is not fully understood why some people develop IBD, but genetics play a role and you are more likely to have it if you have a close relative who has or had IBD. Smokers are more likely to be affected by CD and smoking can aggravate the symptoms, so is worth considering quitting if you do smoke.As vaping is a new trend, it isn’t yet known if there is a link between vaping and IBD.

References

[1]

NHS. Amyloidosis. Accessed May 26, 2022.

[2]

McCausland KL, White MK, Guthrie SD, et al. Light chain (AL) amyloidosis: the journey to diagnosis. The Patient-Patient-Centered Outcomes Research. 2018;11(2):207-16.

[3]

Cancer.Net. Amyloidosis: Symptoms and Signs. Accessed May 26, 2022.

[4]

Mayo Clinic. Amyloidosis overview: symptoms and causes. Accessed May 26, 2022.

[5]

National Organization for Rare Disorders. Amyloidosis. Accessed May 26, 2022.

[6]

D'Errico S, Mazzanti A, Baldari B, Maiese A, Frati P, Fineschi V. Sudden death in lambda light chain AL cardiac amyloidosis: a review of literature and update for clinicians and pathologists. Int J Clin Exp Pathol. 2020 Jul 1;13(7):1474-1482. PMID: 32782665; PMCID: PMC7414507.

[7]

Mayo Clinic. Amyloidosis diagnosis and treatment. Accessed August 20, 2020.

[8]

Lousada I, Comenzo RL, Landau H, et al. Light chain amyloidosis: patient experience survey from the Amyloidosis Research Consortium. Advances in Therapy. 2015;32(10):920-928.

[9]

Merlini G, Dispenzieri A, Sanchorawala V, et al. Systematic immunglobulin light chain amyloidosis. Nature Review Disease Primers. 2018;4(1):38.

[10]

Hasib Sidiqi M, Gertz MA. Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021. Blood cancer journal. 2021;11(5):1-9.